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Etoposide 33419-42-0 with purity >99% Low price in stock We supply high quality Etoposide (CAS 33419-42-0), in stock, factory directly supply to clients, lower prices, more competitiveness.
Etoposide is White crystalline powder, while it's Molecular Formula is C29H32O13. anticonvulsant
The CAS number of Etoposide is 33419-42-0.
More information of Etoposide 33419-42-0 are:
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Synonyms |
Etoposide; 4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-β-D-glucopyranoside); 4‘-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside); |
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CAS Number |
33419-42-0 |
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Molecular Formula |
C29H32O13 |
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Molecular Weight |
588.565 |
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Density |
1.55 g/cm3 |
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Melting Point |
236-251 °C(lit.) |
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Boiling Point |
798.054 °C at 760 mmHg |
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Flash Point |
263.603 °C |
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HS CODE |
29389090 |
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PSA |
160.83000 |
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LogP |
1.33860 |
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Pka |
9.8(at 25℃) |
Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 μM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 μM). It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A . Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 μM). Formulations containing etoposide have been used in combination therapy in the treatment of cancer.
Articles related to Etoposide:
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Article |
Source |
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Dually Enzyme- And Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy |
Yu, Na,Liu, Tao,Zhang, Xi,Gong, Ningqiang,Ji, Tianjiao,Chen, Jing,Liang, Xing-Jie,Kohane, Daniel S.,Guo, Shutao , p. 5465 - 5472 (2020) |
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Preparation method of etoposide, teniposide and analogs of etoposide and teniposide |
- Paragraph 0106; 0107; 0108, (2017/01/02) |
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