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Bulk supply high purity Temozolomide 85622-93-1, Paid sample available We supply high quality Temozolomide (CAS 85622-93-1), in stock, factory directly supply to clients, lower prices, more competitiveness.
Temozolomide is Off-white to light-pink crystalline solid, while it's Molecular Formula is C6H6N6O2. Temozolomide has been used for analyzing drug resistance mechanisms in glioblastoma cell lines15,16.
The CAS number of Temozolomide is 85622-93-1.
More information of Temozolomide 85622-93-1 are:
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Synonyms |
3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide;CCRG 81045;Temozolodida [Spanish];Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-;Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide,3,4-dihydro-3-methyl-4-oxo-;3-methyl-2-oxo-1,3,4,5,8-pentazabicyclo[4.3.0]nona-4,6,8-triene-7-carboxamide;MB 39831;Methazolastone;Temozolomide [BAN:INN];Imidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo-;Temodal;3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide;Temozolomidum [Latin];8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one; |
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CAS Number |
85622-93-1 |
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Molecular Formula |
C6H6N6O2 |
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Molecular Weight |
194.153 |
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Density |
1.97 g/cm3 |
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Melting Point |
212 °C dec. |
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Boiling Point |
526.6 °C at 760 mmHg |
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Flash Point |
272.3 °C |
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HS CODE |
29339900 |
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PSA |
108.17000 |
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LogP |
-1.37780 |
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Pka |
14.77±0.20(Predicted) |
Temozolomide was launched for the first time in the UK for the treatment of patients with glioblastoma multiforme showing recurrence or progression after standard therapy. It can be considered as a cyclic variant of highly reactive triazenes producing a cascade of ionic or radical antitumoral species. Temozolamide is a 3-methyl analog of mitozolomide and was shown to be converted to cytotoxic triazene MCTIC. It can be prepared in 2 steps from 5- aminoimidazole-4-carboxamide by diazotization then cyclization with methylisocyanate. Mechanistically, the depletion of O6-alkylguanine-DNA alkyltransferase (OGAT) in cells or tumors was shown to be correlated with the cytotoxicity of temozolomide which is a potent inhibitor of this enzyme involved in DNA repair activity. Further approval applications for the treatment of other malignant gliomas such as relapsed anaplastic astrocytoma, advanced metastatic melanoma were submitted.
InChI:InChI=1/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
Articles related to Temozolomide:
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Article |
Source |
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Alternative syntheses of the antitumour drug temozolomide avoiding the use of methyl isocyanate |
Wang,Stevens,Thomson , p. 1687 - 1688 (1994) |
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Temozolomide intermediate compound VII |
- Paragraph 0092-00100, (2021/10/13) |
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