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Methotrexate is an antineoplastic and antirheumatic drug that acts as a folic acid antagonist. It is a deuterated form of folic acid, which allows it to cross the blood-brain barrier and exhibit potential anxiolytic and vasodilator activities.
Methotrexate, for example, is highly bound to serum albumin and can be displaced by salicylates, sulfonamides, phenothiazines, phenytoin, and other organic acids. The induction of hepatic drugmetabolizing enzymes by phenobarbital may alter the metabolism of cyclophosphamide to both active and inactive metabolites. Mercaptopurine metabolism is blocked by allopurinol, an occurrence that may result in lethal toxicity if the dosage of mercaptopurine is not reduced to one-fourth of the usual dosage. Methotrexate is secreted actively by the renal tubules, and its renal clearance may be delayed by salicylates.
Used as a antineoplastic and antirheumatic. A folic Acid antagonist
The CAS number of Methotrexate is 59-05-2.
More information of Methotrexate 59-05-2 are:
CAS Number |
59-05-2 |
Density |
1.536 g/cm3 |
Melting Point |
195 °C |
Boiling Point |
561.26°C (rough estimate) |
Flash Point |
11℃ |
Refractive Index |
1.6910 (estimate) |
HS CODE |
29335995 |
PSA |
210.54000 |
LogP |
1.82170 |
Pka |
pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain) |
The chemical formula of Methotrexate is C20H22N8O5 which containing 20 Carbon atoms,22 Hydrogen atoms,8 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight, and the molecular weight of Methotrexate is 454.445
Methotrexate is an antineoplastic and antirheumatic drug that acts as a folic acid antagonist. It is a deuterated form of folic acid, which allows it to cross the blood-brain barrier and exhibit potential anxiolytic and vasodilator activities.
InChI:InChI=1/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m1/s1
Relevant articles related to Methotrexate:
Article |
Source |
METHOTREXATE ANALOGS AND METHODS OF USE |
- , (2022/01/04) |
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