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InChI:InChI=1/C16H19N/c1-13(15-9-5-3-6-10-15)17-14(2)16-11-7-4-8-12-16/h3-14,17H,1-2H3/t13-,14-/m0/s1
Asymmetric reductive amination (ARA) is ...
The invention discloses a method for syn...
Rh-catalyzed one-step synthesis of terti...
The invention discloses a preparation me...
(S)-1-phenyl-ethylamine
acetophenone
1-Phenylethanol
(1S,1'S)-bis(1-phenylethyl)amine
| Conditions | Yield |
|---|---|
|
(S)-1-phenyl-ethylamine; acetophenone;
With
tris(pentafluorophenyl)borate;
In
toluene;
at 60 ℃;
for 8h;
With
ammonia borane;
In
toluene;
at 60 ℃;
for 4h;
Solvent;
Temperature;
diastereoselective reaction;
|
37% 53% |
acetophenone
(S)-1-phenyl-ethylamine
(R)-1-phenyl-ethyl-amine
(1S,1'S)-bis(1-phenylethyl)amine
(R,R)-N,N-bis-(1-phenylethyl)amine
(R,S)-bis(1-phenylethyl)amine
| Conditions | Yield |
|---|---|
|
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; ammonium acetate; hydrogen; toluene-4-sulfonic acid;
In
methanol; dichloromethane;
at 80 ℃;
for 24h;
under 45603.1 Torr;
stereoselective reaction;
Autoclave;
|
4 % ee 12 % ee |
|
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; C37H30NO2P; ammonium acetate; hydrogen; toluene-4-sulfonic acid;
In
methanol; dichloromethane;
at 80 ℃;
for 24h;
under 45603.1 Torr;
Reagent/catalyst;
stereoselective reaction;
Autoclave;
|
26 % ee 6 % ee |
|
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; ammonium acetate; hydrogen; C45H34NO2P; toluene-4-sulfonic acid;
In
methanol; dichloromethane;
at 80 ℃;
for 24h;
under 45603.1 Torr;
Reagent/catalyst;
stereoselective reaction;
Autoclave;
|
66 % ee 18 % ee |
(αS)-α-methyl-N-(1-phenylethylidene)benzenemethanamine
2,2,6-trimethylcyclohexan-1-one
N-(α-methyl)benzylidene 1-phenylethanamine
(S)-1-phenyl-ethylamine
methyl (3R,αR,α'R)-3-(N,N-bis(α-methylbenzyl)amino)butanoate
tert-butyl (3R,αR,α'R)-3-(N,N-bis(α-methylbenzyl)amino)butanoate
benzyl (3R,αR,α'R)-3-(N,N-bis(α-methylbenzyl)amino)butanoate
2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester
CAS:2387600-97-5
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