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Bulk supply high purity Oxaliplatin 61825-94-3, Paid sample available We supply high quality Oxaliplatin (CAS 61825-94-3), in stock, factory directly supply to clients, lower prices, more competitiveness.
Oxaliplatin is White crystalline solid, while it's Molecular Formula is C8H14N2O4Pt. A antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA
The CAS number of Oxaliplatin is 61825-94-3.
More information of Oxaliplatin 61825-94-3 are:
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Synonyms |
Eloxatin;1-OHP;(1R,2R)-cyclohexane-1,2-diamine; oxalic acid; platinum(+2) cation;Eloxatin (TN);Trans-l-diaminocyclohexane oxalatoplatinum;Platinum, (1,2-cyclohexanediamine-N,N)(ethanedioato(2-)-O,O-, (SP-4-2-(1R-trans))-;Platinum, [ (1R,2R)-1,2-cyclohexanediamine-.kappa.N, .kappa.N][ethanedioato(2-)-.kappa.O1,.kappa.O2]-,(SP-4-2)-;(SP-4-2-(1R-trans))-(1,2-Cyclohexanediamine-N,N)(ethanedioato(2-)-O,O)platinum;RP 54780;Oxalatoplatinum;Oxaliplatin EP5; |
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CAS Number |
61825-94-3 |
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Molecular Formula |
C8H14N2O4Pt |
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Molecular Weight |
397.29 |
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Boiling Point |
193.6oC at 760 mmHg |
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Flash Point |
75oC |
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HS CODE |
28439000 |
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PSA |
104.64000 |
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LogP |
0.61450 |
Eloxatin was launched in France for second-line treatment of metastatic colorectal cancer. Oxaliplatin is a second generation platinum drug prepared in three steps from either k2tCl4 or K2Ptl4. It has an antitumor spectrum similar to cisplatin, however, it is more effective against L1210 leukemia and cisplatin resistant L1210. It is also effective against B16 melanoma but has a dose limiting toxicity of peripheral sensory neuropathy that is reversible upon cessation of the drug. The (R,R)- enantiomer has greater activity than the (S,S)-isomer but this is tumor line dependent, e.g., there was no difference found for P-388 or Sarcoma 180. Clinical drug administration based on circadium timing showed it was better tolerated when given 16 h after the onset of light. Oxaliplatin binds to guanineN7 and can lead to bidentate chelation that results in the bending of DNA. This feature is recognized by high mobility group proteins (HMG) which impedes repair reactions and stops replication and transcription.
InChI:InChI=1/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1/rC8H14N2O4Pt/c11-7-8(12)14-15(13-7)9-5-3-1-2-4-6(5)10-15/h5-6H,1-4,9-10H2/t5-,6-/m1/s1
Articles related to Oxaliplatin:
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Article |
Source |
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A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant PtIV Prodrug Activation |
Norman, Daniel J.,Gambardella, Alessia,Mount, Andrew R.,Murray, Alan F.,Bradley, Mark , p. 14189 - 14192 (2019) |
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Phorbiplatin, a Highly Potent Pt(IV) Antitumor Prodrug That Can Be Controllably Activated by Red Light |
Wang, Zhigang,Wang, Na,Cheng, Shun-Cheung,Xu, Kai,Deng, Zhiqin,Chen, Shu,Xu, Zoufeng,Xie, Kai,Tse, Man-Kit,Shi, Peng,Hirao, Hajime,Ko, Chi-Chiu,Zhu, Guangyu , p. 3151 - 3165 (2019) |
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