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Product Details
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Pharmaceutical Applications |
Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin. The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleaving groups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatin has been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular, ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effect is myelosuppression. |
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Brand name |
Aqupla |
InChI:InChI=1/C2H3O3.2H2N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H2;/q3*-1;+4/p-1/rC2H6N2O3Pt/c3-8(4)6-1-2(5)7-8/h1,3-4H2
Octahedral platinum(IV) complexes are pr...
Glycolatoplatinum(II) complexes, , havin...
cis-diaminediiodoplatinum(II)
2K(1+)*Cl4Pt
hydroxyacetic acid silver salt
nedaplatin
| Conditions | Yield |
|---|---|
|
cis-diaminediiodoplatinum(II); 2K(1+)*Cl4Pt; hydroxyacetic acid silver salt;
In
water;
at 20 ℃;
Darkness;
With
Amberlite-HCl;
pH=9 - 10;
Darkness;
|
69% |
cis-diaminedinitroplatinum(II)
sodium glycolate
nedaplatin
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
water;
addn. of sodium glycolate to Pt-complex in H2O; pH was adjusted to 7 with NaOH; stirring for 3 h; concn. at 50-60°C under reduced pressure; filtration; washing (chilled water); drying (vac.); elem. anal.;
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28% |
cis-diaminedinitroplatinum(II)
sodium glycolate
glycolic Acid
cisplatin
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