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Buy cost-effective 99% pure Sorafenib Tosylate 475207-59-1 now We supply high quality Sorafenib tosylate (CAS 475207-59-1), in stock, factory directly supply to clients, lower prices, more competitiveness.
Sorafenib tosylate is White to off-white crystalline powder, while it's Molecular Formula is C21H16ClF3N4O3. An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.
The CAS number of Sorafenib tosylate is 475207-59-1.
More information of Sorafenib tosylate 475207-59-1 are:
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Synonyms |
Sorafenib tosylate [USAN];1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate);4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate);BAY 43-9006;Nexavar(R);UNII-5T62Q3B36J;2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-, mono(4-methylbenzenesulfonate); |
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CAS Number |
475207-59-1 |
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Molecular Formula |
C21H16ClF3N4O3 |
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Molecular Weight |
637.03 |
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Density |
1.454 g/cm3 |
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Boiling Point |
523.3 °C at 760 mmHg |
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Flash Point |
270.3 °C |
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HS CODE |
29159000 |
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PSA |
155.10000 |
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LogP |
8.40910 |
Sorafenib (475207-59-1) was initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-β (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM).1?Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms.2?Inhibits activation of MAPK pathway and ERK phosphorylation.3?Induces caspase-independent apoptosis in melanoma cells.4?Sorafenib is a clinically useful anticancer agent.
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